Endocrine Abstracts

Introduction: Autoimmune polyendocrine syndrome ( APS ) is a rare, inherited disorder, characterized by autoimmune thyroiditis with another organ specific autoimmune disease.ObservationWe report the case of 55 years old woman, descendant of a first degree consanguineous marriage, who presented at the age of 35 a premature ovarian insufficiency and alopecia. Eight months later, she developed a goiter with hyperthyroidism and the dia...

Multiple endocrine neoplasia type 1 (MEN1) is a rare but misleading disease. The diagnosis is evocated when two main lesions are present (parathyroid, pituitary gland, endocrine pancreas tumor: Gastrinoma). We studied a 36 year-old woman hospitalized in orthopedics for a neck femur fracture. A hypercalcaemia (Ca++=2.84 mmol/l) with elevated PTH=500 pg/ml were discovered before intervention. The bone biopsy concluded to primary hyperparathyroidism lesions.<p class="abstext"...

We report a 25 years old man who admitted in our department for primary hyperparathyroidism. He has previously been diagnosed with urolithiasis in 2006 and two pathological fracture of the humerus in 2009.Physical exam was normal laboratory findings showed hypercalcemia (4.06 mmol/l) associated to a high parathyroid hormone level (PTH: 1930 pg/ml).Ultrasound examination of the neck showed two enlarged parathyroid adenoma.<p cla...

Spontaneous pregnancy in the course of Sheehan syndrome is extremely rare because of gonadotrophic insufficiency, which is almost present.The aim of our study is to analyse cases of pregnancies occurring spontaneously in patients with Sheehan syndrome.It is a retrospective study of 46 women who had a Sheehan syndrome diagnosed in the Internal Medicine and endocrinology department of Charles Nicolle Hospital during the period betwee...

Sheehan syndrome is a global or partial pituitary defect occurring after an obstetrical haemorrhage.The aim of this study is to describe metabolic complications in 46 consecutive patients with Sheehan syndrome and to determine correlations between these complications and the clinical, hormonal and therapeutic aspects of this syndrome.All patients have had a physical examination: weight measurement, body mass index (BMI) determinati...

We present a 58 years old woman admitted in our department for bradycardia, diarrhea, epigastralgia, anorexia and weight loss. Physical examination showed low blood pressure and inability to walk or stand due to severe flexion contractures of the lower extremities without neurological abnormalities. The biological findings showed severe hyponatremia, hyerkaliemia tendency, low levels of plasma cortisol and ACTH suggesting pituitary adrenal axis deficiency. Hormonal investigati...

Diabetes in paraneoplastic Cushing is often severe with a risk of acute metabolic complications.Observation n° 1: A 36-year-old patient, with no medical history, was hospitalized for inaugural diabetic ketoacidosis with no intercurrent infection. The physical examination found facio-truncal obesity, amyotrophy of extremities, melanoderma, arterial hypertension and severe psychiatric disorders. The blood tests showed an hypokalemia at 1.9 mmol/l. Hig...

Endogenous Cushing’s syndrome comes generally with permanent hypercorticism often complicated by diabetes which can be difficult to control. However, the cortisol’s excessive production may be cyclic or intermittent, and, therefore, complications may have a specific course which leads to diagnostic and therapeutic delay.Observation: We report the case of a 28-year-old woman with no previous medical history who was hospitalized for a Cushing&#14...

IntroductionPheochromocytomas are rare catecholamine-producing neuroendocrine tumors derived from the sympathetic or parasympathetic nervous system. The clinical presentation of pheocromocytoma has varying forms, which makes diagnosing it challenging. Here, we report a case of Adrenergic cardiomyopathy mimicking COVID-19.Case reportA 40-year-old woman with a history of pulmonary edema during cesarean delivery...

BackgroundHypoglycemia is a well-established as a serious paraneoplastic complication of hepatocellular carcinoma (HCC). However, hypoglycemia presenting the first presentation of HCC is not frequent. In this regard, we present the case of a patient who had hypoglycemia as first manifestation of HCC.ObservationA 55yearold man presented to the Emergency Department with loss of consciousness preceded by dizzine...